Equine Refined Equine Rabies Immunoglobulin 1500 I.U. Potency not less than 300 IU/ml.

Antirabies Serum is of equine origin derived from the plasma of the horses, ponies, mules that have been hyperimmunized against rabies. The serum obtained from plasma contains purified, enzyme-refined and concentrated specific immunoglobulins. It is used as a passive immunizing agent and affords protection to the persons suspected of exposure to rabies.

Each ml contains Enzyme-refined Equine Immunoglobulin Not less than 300 I.U. Phenol I.P. Not more than 0.25% w/v.

Solution for injection by intramuscular or subcutaneous route. 5.0 ml per vial, 1500 I.U.

For the treatment of category III bites for patients at risk being exposed to rabies after contact with confirmed or suspected rabid animal.
(Category III bites -major bites on head, face, neck or finger, single or multiple transdermal bites or scratches. Lacerated wounds on any part of the body. Contamination of mucous membrane with saliva. All jackal and wolf bites,)
It should be given as soon as possible after exposure preferably within 24 to 48 hours as it contains readymade antibodies. These antibodies confer passive immunity against rabies infections.
It must be injected as soon as possible locally to permit direct and rapid in-site neutralization of positive virus. Antirabies serum alone does not guarantee an Antirabies treatment and should always be combined with Antirabies vaccination.

They are many immediate or delayed allergic type reactions. The observed immediate reactions are anaphylactic reactions with hypotension, dyspoea and unticaria.Delayed reaction consist of inflammatory reaction, fever pruritus rash o urticaria, adenopathy and arthralgias.Anaphylactic reactions can occur during and after the treatment even it the hypersensitivity test is negative. Anaphylactic reaction can occur even with the test.

• Elicit history of  familial allergic disorders such as asthma,
• Eczema, drug all allergy from the patient.
• Whether the patient had received earlier, injection of serum such as ant tetanus serum , Antidiphtheria, serum snake Antivenin or scorpion venom Antiserum etc.
• Carry out the sensitivity test on the patient. Inject subcutaneously 0.1 ml. of the serum diluted 1:10 Observe the patient for 30 minutes for local or general reaction if any.
• Keeps handy injection Adrenaline (Epinephrine) 1 ml of 1:1000 along with antihistanminesand steroids to meet any emergency arising out of sensitivity reactions.
• After administering the full dose of serum the patient should be keep under observation  for at latest 30 minutes.
• In sensitivity individual it is advisable to administer Antirabies Serum under the cover of injection Adrenaline  (Epinephrine) 1 ml ( 1:1000) intramuscular and Antihistamines.

Rabies prevention after contamination risk requires simultaneous  administration  of Antirabies Serum and vaccine. Antirabies Serum and  vaccine must be given in the Separates sites to avoid insite neutralization. Antirabies serum should be administered in the same syringes as the vaccine.

The use of human AntiRabies immunoglobulin is preferable.
The safety of this medical product when used during Pregnancy has not been established in clinical trials in humans Considering the lethal risk associated with rabies, Pregnancy is not a contraindication to be administration of Antirabies treatment subsequent exposure.

Prompt local treatment of bite wounds and scratches that may be contaminated with Rabies virus is important whatever the time elapsed since the contact.
Recommended first aid procedure are immediate through flashing and washing of the would with soap and water, detergent or other substance of proven lethal effect of rabies virus.
Anti Rabies Serum should be injected as soon as possible after exposure.
Anti Rabies Serum should be given to all category III bite cases provide the patient seeks treatment within 7 days of bite.
Recommended dose 40 IU / kg. body weight up to maximum of 3000. I .U.
Maximum possible of the required dose should be infiltrated around the wounds, if anatomically feasible.
The first dose of vaccine should be inculcated at the same time as the immunoglobulin but in a different part of the body (upper part of arms Deltoid region)
In no cases should the dosage of the Antirabies Serum be the exceeded because immunoglobulin may partially suppress active production of antibodies.
Children and adults receive the same dose of 40 IU/Kg of body weight.
When indicated, begin anti-tetanus treatment and administer antimicrobial drugs to control infections other than rabies.

• World Health Organization WHO expert committee on Rabies, 8th
  report WHO Tech rep Ser 1992,824, 1-84.
• Wilde H., Purified equine Rabies immunoglobulins. a safe and affordable alternative to human rabies immunoglobulins. Bull. WHO 1989, 67,731-736.
• Meslin F.X., Kaplan M. M. and Koprowsky H. (1996); Laboratory Techniques in rabies, 4th edition WHO Geneva.